Pesticides >> Insecticide >> Methomyl

Methomyl

Methomyl 98%TC
Methomyl 90%SP
Methomyl 40%SP
Methomyl 20%EC

Insecticide, acaricide
oxime carbamate

NOMENCLATURE
Common name methomyl (BSI, E-ISO, (m) F-ISO, ANSI, ESA, JMAF)
IUPAC name S-methyl N-(methylcarbamoyloxy)thioacetimidate
Chemical Abstracts name methyl N-[[(methylamino)carbonyl]oxy]ethanimidothioate
CAS RN [16752-77-5] EEC no. 240-815-0 Development codes DPX-X1179 (Du Pont) Official codes OMS 1196

APPLICATIONS
Biochemistry Cholinesterase inhibitor. Mode of action Systemic insecticide and acaricide with contact and stomach action. Uses Control of a wide range of insects (particularly Lepidoptera, Hemiptera, Homoptera, Diptera and Coleoptera) and spider mites in fruit, vines, olives, hops, vegetables, ornamentals, field crops, cucurbits, flax, cotton, tobacco, soya beans, etc. Also used for control of flies in animal and poultry houses and dairies. Phytotoxicity Non-phytotoxic when used as recommended, except to some varieties of apple. Formulation types SL; SP; WP. Selected tradenames: 'Lannate' (Du Pont); 'Dimethilin' (Efthymiadis); 'Dunet' (Dhanuka); 'Kuik' (Rotam); 'Methavin' (Aventis); 'Methomex' (Makhteshim-Agan); 'Methosan' (Sanachem); 'Nudrin' (BASF); 'Pilarmate' (Pilarquim); 'Sathomyl' (Sanonda); mixtures: 'Flybait' (+ muscalure) (Denka)

Methomyl OTHER TRADENAMES
'Agrinate' (Vapco); 'Arizona' (Rocca); 'Kipsin' (Aventis); 'Lanox' (Crystal); 'Mieduowei' (Shenzhen Jiangshan) mixtures: 'Goldben' (+ muscalure) (Vapco); 'Last Dream PBW' (+ chlorpyrifos+ gossyplure) (Troy Biosciences); 'Methofan' (+ endosulfan) (Makhteshim-Agan); 'Metofan forte' (+ endosulfan) (Aragonesas); 'Sepiclar T' (+ tetradifon) (Griffin); 'Stimukil' (+ muscalure) (Troy Biosciences) Discontinued names: 'Halvard' * (Shell) mixtures: 'Golden Malrin Fly Bait' * (+ muscalure) (Novartis A H)

ANALYSIS
Product analysis by hplc (J. E. Thean et al., J. Assoc. Off. Anal. Chem., 1978, 61, 15; R. E. Leitch & H. L. Pease, Anal. Methods Pestic. Plant Growth Regul., 1973, 7, 331). Residues determined by glc with FPD (idem, ibid.; R. T. Krause, J. Assoc. Off. Anal. Chem., 1980, 63, 1114; M. A. Luke et al., ibid., 1981, 64, 1187; A. Ambrus et al., ibid., p. 733) or by rplc (AOAC Methods, 1995, 985.23). Details available from Du Pont. For methods in drinking water, see AOAC Methods, 1995, 991.06.

MAMMALIAN TOXICOLOGY
Reviews CAG (see part 2 of Bibliography). Oral Acute oral LD50 for male rats 34, female rats 30 mg/kg. Skin and eye Acute percutaneous LD50 for male and female rabbits >2000 mg/kg. Mild eye irritant (rabbits). Not a skin irritant (guinea pigs). Inhalation LC50 (4 h) for rats 0.3 mg/l air (aerosol). NOEL (2 y) for rats 100, mice 50, dogs 100 mg/kg diet. ADI (JMPR) 0.03 mg/kg b.w. [1994]. Toxicity class WHO (a.i.) Ib; EPA (formulation) I, IV EC hazard T+; R28| N; R50, R53

ECOTOXICOLOGY
Birds Acute oral LD50 for mallard ducks 15.9, pheasants 15.4 mg/kg. Dietary LC50 (8 d) for Pekin ducks 1890, bobwhite quail 3680 mg/kg diet. Fish LC50 (96 h) for rainbow trout 3.4, bluegill sunfish 0.9 mg/l. Daphnia LC50 (48 h) 31.7 mg/l. Algae EC50 (72 h) 60 mg/l. Bees Toxic to bees, contact LD50 0.1 mg/bee, but not hazardous when the spray has dried. Worms LC50 (14 d) 23 mg/kg dry soil.

ENVIRONMENTAL FATE
EHC 178 (WHO, 1996). Methomyl Health & Safety Guide: 97 (WHO 1995). Animals In rats, methomyl was rapidly converted to methomyl methylol, oxime, sulfoxide and sulfoxide oxime; these unstable intermediates were converted to acetonitrile and CO2, which were eliminated primarily via respiration and in the urine. Metabolism of carbamate insecticides is reviewed (M. Cool & C. K. Jankowski in "Insecticides"). Plants DT50 following leaf application c. 3-5 d. Rapidly degraded to CO2 and acetonitrile, with incorporation into natural plant components (J. Harvey & R. W. Reiser, Agric. Food Chem., 1973, 21, 775). Soil/Environment Rapidly degraded in soil. DT50 in groundwater samples <0.2 d (J. H. Smelt, Pestic. Sci., 1983, 14, 173-181). Koc 72.