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Iprodione

Iprodione 95%TC
Iprodione 50%SC

Fungicide
FRAC 2; dicarboximide

Iprodione NOMENCLATURE
Common name iprodione (BSI, E-ISO, (m) F-ISO, ANSI)
IUPAC name 3-(3,5-dichlorophenyl)-N-isopropyl-2,4-dioxoimidazolidine-1-carboxamide
Chemical Abstracts name 3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide
Other names glycophene* (rejected common name proposal) CAS RN [36734-19-7] EEC no. 253-178-9 Development codes 26 019 RP (

Iprodione APPLICATIONS
Mode of action Contact fungicide with protective and curative action. Inhibits germination of spores and growth of fungal mycelium. Uses Control of Botrytis, Monilia, Sclerotinia, Alternaria, Corticium, Fusarium, Helminthosporium, Phoma, Rhizoctonia, Typhula spp., etc. Used mainly on sunflowers, cereals, fruit trees, berry fruit, oilseed rape, rice, cotton, vegetables, and vines as a foliar spray, at 0.5-1.0 kg a.i./ha, and on turf, at 3-12 kg/ha. Can also be used as a post-harvest dip, as a seed treatment, or as a dip or spray at planting. Formulation types DP; EC; FS; SC; SU; WG; WP. Selected tradenames: 'Kidan' (Aventis); 'Rovral' (Aventis); 'Verisan' (Aventis); 'Botrix' (Agrimix)

Iprodione OTHER TRADENAMES
'Dirac' (Aventis); 'Diva' (Aventis); 'Amazzones' (Rocca); 'Rover' (Vapco); 'Viroval' (Vipesco) mixtures: 'But' (+ bromuconazole) (Aventis); 'Calidan' (+ carbendazim) (Aventis); 'Chipco' (+ fosetyl-aluminium) (Aventis); 'Compass' (+ thiophanate-methyl) (Aventis); 'Snooker' (+ thiophanate-methyl) (Aventis); 'Pacha' (+ carbendazim) (Philagro)

ANALYSIS
Product analysis by hplc or glc (CIPAC Handbook, 1995, G, 98-104; L. Lacroix et al., Anal. Methods Pestic. Plant Growth Regul., 1980, 11, 247). Residues determined by glc with ECD (idem, ibid.; Man. Pestic. Residue Anal., 1987, I, 6, S8, S19; Anal. Methods Residues Pestic., 1988, Part I, M1, M12).

MAMMALIAN TOXICOLOGY
Reviews FAO/WHO 74, 76 (see part 2 of the Bibliography). Oral Acute oral LD50 for rats and mice >2000 mg/kg. Skin and eye Acute percutaneous LD50 for rats and rabbits >2000 mg/kg. Non-irritating to skin and eyes (rabbits). Inhalation LC50 (4 h) for rats >5.16 mg/l air. NOEL (2 y) for rats 150 mg/kg diet; (1 y) for dogs 18 mg/kg b.w. ADI (JMPR) 0.06 mg/kg b.w. [1995]. Toxicity class WHO (a.i.) III (Table 5); EPA (formulation) IV

Iprodione ECOTOXICOLOGY
Birds Acute oral LD50 for bobwhite quail >2000, mallard ducks >10 400 mg/kg. Fish LC50 (96 h) for rainbow trout 4.1, bluegill sunfish 3.7 mg/l. Daphnia LC50 (48 h) 0.25 mg/l. Algae EC50 (120 h) for Selenastrum capricornutum 1.9 mg/l. Bees Contact LD50 >0.4 mg/bee. Worms LC50 for earthworms >1000 mg/kg soil. Other beneficial spp. Harmless.

ENVIRONMENTAL FATE
Animals In rats, ruminants and birds, iprodione is rapidly eliminated. It also undergoes extensive metabolism, by hydrolysis and rearrangement reactions. Plants Metabolism studies in cereals, fruit, leafy and oily crops showed that iprodione is the dominant component of the total residue resulting from foliar application. Soil/Environment Rapidly metabolised in soil, with formation of CO2. DT50 (lab.) 20-80 d; (field) 20-160 d. Koc 373 to 1551. Rate of degradation increases with successive treatments, hence accumulation does not occur.