Products >> Fungicides >> Dodine

Dodine 50%SC

Dodine NOMENCLATURE
Common name dodine (BSI, E-ISO, (f) F-ISO, ANSI); doguadine (France); tsitrex* (former exception, USSR); dodine acetate* (BSI, before 1969)
IUPAC name 1-dodecylguanidinium acetate
Chemical Abstracts name dodecylguanidine monoacetate
CAS RN [2439-10-3] EEC no. 219-459-5 Development codes CL 7521; AC 5223 (both Cyanamid)

dodine free base
Common name guanidine (JMAF); dodine* (BSI, before 1969)
CAS RN [112-65-2]

Dodine APPLICATIONS
Mode of action Foliar fungicide with protective and some curative action. Uses Dodine is used for control of scab on apples, pears, and pecans; leaf spot diseases of cherries, olives, blackcurrants, celery, and other crops; and foliar diseases of strawberries. Also used on other fruit, vegetable, nut, and ornamental crops, and on shade trees. Applied at 30-80 g a.i./100 l (0.25-1.5 kg/ha). Phytotoxicity Peaches, plums, vines, and raspberries may be injured. Russetting may occur on some varieties of apple (including Golden Delicious). Formulation types SC; SL; WP. Compatibility Incompatible with anionic surfactants, chlorobenzilate, lime sulfur, oils, oil emulsions, and hard water. Selected tradenames: 'Cyprex' (BASF); 'Venturol' (BASF); 'Dodene' (Sipcam); 'Dodex' (Barclay); 'Efuzin' (Agrokémia); 'Guanidol' (Caffaro); 'Melprex' (BASF, Aventis); 'Sulgen' (General Quimica)

Dodine OTHER TRADENAMES

'Dodylon' (Papaeconomou); 'Karp-N' (Chemiplant); 'Radspor' (Truchem); 'Syllit' (Aventis, UAP)

ANALYSIS
Product analysis by titration in non-aqueous media (CIPAC Handbook, 1983, 1B, 1802; AOAC Methods, 1995, 970.07). Residues determined by colorimetry of a complex (ibid., 964.19; Pestic. Anal. Man., 1979, II; G. L. Sutherland, Anal. Methods Pestic., Plant Growth Regul. Food Addit., 1964, 3, 41).

MAMMALIAN TOXICOLOGY
Reviews FAO/WHO 89, 91 (see part 2 of the Bibliography). Oral Acute oral LD50 for male rats c. 1000 mg/kg. Skin and eye Acute percutaneous LD50 for rabbits >1500, rats >6000 mg/kg. Irritating to skin. NOEL In 2 y feeding trials, rats receiving 800 mg/kg diet suffered a slight retardation of growth with no effect on reproduction or lactation. ADI (JMPR) 0.1 mg/kg b.w. [2000]. Toxicity class WHO (a.i.) III; EPA (formulation) I EC hazard Xn; R22| Xi; R36/38| N; R50, R53

ECOTOXICOLOGY
Birds Acute oral LD50 for mallard ducks 1142, Japanese quail 788 mg/kg. Fish LC50 for harlequin fish (48 h) 0.53 mg/l; (96 h) 0.6 mg/l. Bees Topical LD50 for honeybees >0.011 mg/bee.

ENVIRONMENTAL FATE
Animals In rats, 95% of the applied dose is eliminated in urine and faeces within 8 d; c. 74% of excreted material is unchanged dodine; metabolites include creatine and guanidine derivatives. Plants In plants, dodine is converted to creatine by the action of a methyltransferase and simultaneous oxidative cleavage of the dodecyl moiety.